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Proluton Depot Injection contains hydroxyprogesterone as its active ingredient. It is used in reducing the risk of premature birth in a female who previously has delivered a premature baby. Proluton injection will be given to you under the skin as an injection in a hospital or clinic by a doctor or nurse. It is essential to inform your doctor if you are pregnant, planning a pregnancy or breastfeeding, and about all the medicines, and supplements you take and all the conditions or diseases you suffer from, before starting treatment with this injection.